Diterpene compounds called Grayanotoxins are present in all parts of the plant including the nectar.
Grayanotoxins bind to sodium channels in heart, nerve and muscle causing mainatining cells in a state of depolarization.
Ingestion of 0.2-0.6% of the animals body weight of green laurel leaves will cause poisoning.
Indigenous to North America, Kalmia's 6 species are perennial,evergreen, spring flowering shrubs. The leathery green, lanceolate, leaves are poisonous
Excessive salivation, reurgitation of rumen contents, vomiting, abdominal pain, anorexia. Diarrhea is uncommon.
Muscle tremors, weakness, ataxia and recumbency
Activated charcoal via stomach tube, saline cathartics are helpful in clearing the plant from the digestive tract. Atropine may be necessary iwhere bradycardia is severe.
Increased heart rate, heart irregularity. In severe cases of poisoning the heart may be abnormally slow.
Increased respiratory rate. Death often results from inhalation pneumonia.
Muscle tremors, recumbency, seizures, convulsions
Fetal mummification may occur
Autopsy findings are generally non specific and include hemorrhagic enteritis, and aspiration pneumonia. Kalmia leaf parts may be fopund in the stomach.
"Mad honey" disease occurs in people who eat quantities of honey made from bees feeding on laurels and rhododendrons. Affected people develop excessive salivation, bradycardia, sever hypotension, muscle weakness, convulsions and coma in severe cases.