E Christopher Orton

Contact Information

Office: A206 VTH
Office Phone: 970-297-1250
Email: Chris.Orton@ColoState.EDU

Biography

Dr. Orton is Professor of Cardiology. Dr. Orton established the clinical cardiology service at CSU and began an open heart surgery program for dogs in 1991. This program is credited with many firsts in the area of canine heart surgery and is recognized as the premier center for canine heart surgery in North America. Dr. Orton heads an NIH-funded research program in heart valve pathobiology and tissue engineering. Recent work in Orton’s lab has pioneered the use of in vitro methods for analysis of gene transcription in heart valves subjected to strain that models hypertensive disease.

Degrees

PhD, Colorado State University, 1989

DVM, Washington State University, 1978

MS, Ohio State University, 1982

BS, Oregon State University, 1974

Certifications

Clinical, Diplomate - American College of Veterinary Surgeons

Species Interests

Small Animal Exclusive/Predominant (including pet exotics)

Publications

: Arai S, Lacerda CMR, Orton EC. Tissue-gel electrophoresis enhances antigen removal from porcine aortic valve and bovine pericardium. J Heart Valve Dis 19:753-758, 2010.

: Disatian S, Lacerda C, Orton EC. Tryptophan hydroxylase 1 expression is increased on phenotype-altered canine and human degenerative myxomatous mitral valves. J Heart Valve Dis 19:71-78, 2010.

: Scruggs SM, Disatian S, Orton EC. Serotonin transporter is down-regulated in late-stage canine degenerative mitral valve disease. J Vet Cardiol 12:163-169, 2010.

: Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon J, Carter L, Orton EC. Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome. J Vet Cardiol, 13:91-99, 2011.

: Lacerda CMR, Kisiday J, Johnson B, Orton EC. Local serotoinin mediates tensile strain-induced phenotype transformation and matrix alteration in cultured mitral valves. Am J Physiol: Heart & Circ 302:H1983-H1990, 2012.

: Lacerda CMR, MacLea H, Kisiday J, Orton EC. Static and cyclic tensile strain induce serotonin and myxomatous effector proteins in canine mitral valves. J Vet Cardiol 14:223-230, 2012.

: Lacerda CMR, Orton EC. Evidence of a role for tensile loading in the pathogenesis of mitral valve degeneration. J Clin Experi Cardiol, 2012. doi:10.4172/2155-9880.S3-004.

: Orton, EC, Lacerda CMR, MacLea HB. Signaling pathways in mitral valve degeneration. J Vet Cardiol 14:7-17, 2012.

: Orton, EC. Mitral valve degeneration: Still more questions than answers. J Vet Cardiol 14:3-5, 2012.

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